Michigan State vs Louisville live updates: Start time, channel for March Madness game

Matthew Glenesk and Scooby Axson, USA TODAYSat, March 21, 2026 at 5:15 PM UTC

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Follow all of Saturday's NCAA Tournament second round games with USA TODAY Sports' live updates.

Tom Izzo is "Mr. March."

The Michigan State basketball coach has led the Spartans to 28 straight NCAA tournament appearances, with an overall record of 60-26 in March Madness games.

On Saturday, he'll have a chance at his 17th Sweet 16.

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The No. 3 seed Spartans will have to get through No. 6 Louisville first in Saturday's East Region second round game in Buffalo.

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The Cardinals will once again be without star freshman point guard Mikel Brown Jr. A back injury kept him out of Louisville's first round win over South Florida and will keep him sidelined through the tournament's first weekend.

Louisville led comfortably for most of its win over USF until some late nervy moments. Isaac McKneeley led the Cardinals with 23 points, which included going 7-of-10 from behind the arc. As a whole, Louisville shot 52% from behind the arc. The Cardinals will need that type of hot shooting to knock off the usually rugged Spartans.

Here's what you for today's second round showdown:

HIT REFRESH FOR UPDATES.

What time is Michigan State vs Louisville? -

Time: 2:45 p.m. ET, Saturday.

What channel is Michigan State vs Louisville? Streaming, how to watch -

The game is airing on CBS and streaming on Paramount+.

Michigan State vs Louisville prediction, live odds -

Ehsan Kassim: Michigan State

Jordan Mendoza: Michigan State

John Leuzzi: Michigan State

Blake Schuster: Michigan State

Moneyline: Michigan State (-210); Louisville (+170)

Spread: Michigan State (-4.5)

Over/under total: 151.5

Mikel Brown Jr. injury update: Will Louisville star play today vs Michigan State?

Prior to the Cardinals' first round game against South Florida, Louisville announced Brown wouldn't play in the opener and would also miss the second round game, should they advance.

Brown, who's projected to be an NBA lottery pick later this year, has been sidelined for the Cardinals' past five games (and 13 total this season). Pat Kelsey said Brown re-aggravated a back injury, which surfaced in mid-December, by taking some hard falls during a Feb. 23 loss at then-No. 19 North Carolina.

This article originally appeared on USA TODAY: Michigan State vs Louisville live score update: March Madness time, TV channel

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